Did you notice that the short interest in ACHN increased over ten-fold in the two week period 12/15/09 to 12/31/09?
There are still only about 4% of shares short as of 12/31/09 according to Yahoo. That's not much at all. But, I guess you're implying that the spike is possible evidence that someone knew of, and acted upon, the forthcoming offering. I don't normally pay much attention to short interest ratios or spikes in them, but perhaps that's something to consider in the future.