Replies to post #34529 on ajtj99's Market Pulse

[jrintl]

If its turning (down) it has to do it here, correct (for your scenario, move to 1392,then 1425 to be intact?)

[jjstingray]

I took it quite a bit for my back pain. Laddered it with my pain killers. Hell, if I was having a heart attack, I never would have known it. I was still taking it up until a couple weeks ago. Scary stuff.

[jdaasoc]

RE COX2 Inhibitors.

It is always tough to design a newer, better, small molecule drug that is less water soluble so it doesn't pass though the kidneys as quickly vs adding too much alphatic moieties on to active portion of the drug that makes it hang around in the body too long leading to unwanted side effects. Most drugs aren't very good for you in a accumulative sense. If you take enough pills for a long enough time, side effects do occur.

I am sure PFE is redoubling their long term usage studies. I think Monsanto's GD Serle unit was many months ahead of MRK with Celerbrex's initial development. Maybe MRK rushed things trying to catch up.