Niaspan vs. Zetia: I'm betting on Niaspan. the outcome measure for the study was artery wall thickness and all subjects were already on a statin medication. Zetia's mechanism should not, at least in theory, have a significant impact on LDL plaques already accumulated within artery walls while Niaspan should.
(MRK ABT) Idit et al: How are you handicapping the halted Niaspan vs Zetia study? T.i.a.
You should refer the question to Allen et al :-) We know safety was not the reason. I doubt it was stopped due to Zetia's effectiveness or Niaspam's superiority. The more likely reason for termination, imo, is that Niaspan arm did not show any meaningful effect on mean change in the intima media thickness (IMT).
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