Like Dewo has pointed out, didn't vertex show RVR without Rib doesn't translate to SVR? Its clear that Rib doesn't increase RVR when added to lambda, does that mean Rib should be removed?
"However, ribavirin’s low efficacy as a monotherapy does not imply that it has little incremental value in achieving RVR in combination with interferon; to the contrary, no less an authority than Josh Boger thinks that this is ribavirin’s main contribution in HCV therapy!"
did boger state this before or after PROVE 2 came out? because telaprevir and interferon without rib produces dramatic reductions in VL - way more than rib plus interferon - yet SVR in prove 2 for soc was better than telaprevir (minus rib). so it must follow that inhibition of relapse (and/or late rebound on treatment) is the primary moa by which rib acts to improve svr
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