Actually I will go out on a limb and say Telaprevir (just it and not any possible followons from VRTX) never reaches 1 billion in annual peak sales, I would think it would be closer to 500 million than 1 billion. But of course they could come out and price it at 90k (or whatever that ridiculuously high figure was) and prove me wrong in year 3 or so :-).