VRTX said they will initiate combo study of telaprevir and a ViroChem's polymerase inhibitor later this year.
Nucs have a high genetic barrier to resistance and can exhibit antiviral activity as strong as protease inhibitors, so it's a good combo. But we might see other combos like with Cyclophilin inhibitor, that may be less prone to resistance and could be a candidate used together with direct antivirals trying to replace IFN in the future HCV cocktail.
By well tolerated I mean the drug can be taken for 24 weeks with little discontinuation. Vertex and SGP's protease inhibitors are not well tolerated in my opinion.
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