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Re: DewDiligence post# 74905

Tuesday, 03/24/2009 5:23:26 AM

Tuesday, March 24, 2009 5:23:26 AM

Post# of 257570
VRTX said they will initiate combo study of telaprevir and a ViroChem's polymerase inhibitor later this year.

Nucs have a high genetic barrier to resistance and can exhibit antiviral activity as strong as protease inhibitors, so it's a good combo. But we might see other combos like with Cyclophilin inhibitor, that may be less prone to resistance and could be a candidate used together with direct antivirals trying to replace IFN in the future HCV cocktail.

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