<<t’s the possibility of permanent iris pigmentation, not temporary eyelid pigmentation, that might render Latisse a non-blockbuster.>>
Also, the change in iris color is not a sudden side effect (see below from the Lumigan package insert). If you are concerned enough about your appearance to bother with the product at all, it's not much of an imposition to look at your iris to watch for changes. I would imagine you would be able to catch this before it becomes noticeable to others.
PRECAUTIONS General: LUMIGAN® (bimatoprost ophthalmic solution) 0.03% may gradually increase the pigmentation of the iris. The eye color change is due to increased melanin content in the stromal melanocytes of the iris rather than to an increase in the number of melanocytes. This change may not be noticeable for several months to years (see WARNINGS). Typically, the brown pigmentation around the pupil spreads concentrically towards the periphery of the iris and the entire iris or parts of the iris become more brownish. Neither nevi nor freckles of the iris appear to be affected by treatment. While treatment with LUMIGAN® can be continued in patients who develop noticeably increased iris pigmentation, these patients should be examined regularly. During clinical trials, the increase in brown iris pigment has not been shown to progress further upon discontinuation
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