Biotech Values

[mouton29]

<<t’s the possibility of permanent iris pigmentation, not temporary eyelid pigmentation, that might render Latisse a non-blockbuster.>>

Also, the change in iris color is not a sudden side effect (see below from the Lumigan package insert). If you are concerned enough about your appearance to bother with the product at all, it's not much of an imposition to look at your iris to watch for changes. I would imagine you would be able to catch this before it becomes noticeable to others.

PRECAUTIONS
General: LUMIGAN® (bimatoprost ophthalmic solution) 0.03% may gradually
increase the pigmentation of the iris. The eye color change is due to increased
melanin content in the stromal melanocytes of the iris rather than to an increase
in the number of melanocytes. This change may not be noticeable for several
months to years (see WARNINGS). Typically, the brown pigmentation around the
pupil spreads concentrically towards the periphery of the iris and the entire iris
or parts of the iris become more brownish. Neither nevi nor freckles of the iris
appear to be affected by treatment. While treatment with LUMIGAN® can be
continued in patients who develop noticeably increased iris pigmentation, these
patients should be examined regularly.
During clinical trials, the increase in brown iris pigment has not been shown to
progress further upon discontinuation

http://www.allergan.com/assets/pdf/lumigan_pi.pdf