Replies to post #2060 on SurModics Inc (SRDX)

[bridgeofsighs]

re:stent maker is using what srdx technologies

On the market
JNJ Cypher-drug delivery polyner.
Cypher select plus OUS-drug delivery polymer and hydrophilic
MDT Endeavour-Hydrophilic
ABT XIENCE-no
BSX Taxus-no
BSX Promus-no

Pipeline
Xtent-hydrophilic
CardioMind Sparrow-drug delivery polymer.
Paragon-Apollo Therapeutics-Finale coating.
Next generation Connor stent???
X-Cell-drug delivery polymer my guess is dead on the vine.

[DewDiligence]

Re: Avastin

>one thing I still don't get… as Dew reports Avastin seems to be the choice drug for back of eye disease… but still you need frequent shots… why wouldn't they at least experiment with Avastin on the eye tack?<

It’s a cost/benefit tradeoff.

Standalone Avastin is far from ideal for treating retinal diseases, but it costs virtually nothing to administer. A compounding pharmacist can aliquot a single 400mg vial intended for treating cancer into a large number of ophthalmic-sized doses. Genentech initially tried to prevent this by refusing to ship to compounding pharmacists, but they had to back down in the face of a blistering backlash from the AAO.

Consequently, any product—whether drug or device—that has a realistic chance to garner a premium price in the AMD/DME market will not merely have to be clinically superior to Avastin—it will have to blow it away. I don’t think the InnoRx platform has the potential to do this and MRK doesn’t either, evidently. Regards, Dew

[Democritus_of_Abdera]

Stents...

Bruce Barclay provided some additional information regarding Surmodic’s involvement in the drug eluting stent market at the Feb 2, 2009 annual meeting. In particular, he stated:

“Today we have licensed our technology to 12 different companies, some on multiple products, and we have royalty rates better than Cypher in most cases.”

Eleven companies were listed on slide 21 of the presentation. I have bolded these in the list below (Cordis and Conor were listed separately).

My list of stent relationships has been updated to read:

1. JNJ (Cordis & Conor)

Cypher Sirolimus eluting stent – Bravo Drug Delivery Polymer Matrix; http://www.surmodics.com/technologies-delivery-durable.html

Cypher Select Plus/Elite Sirolimus eluting stent delivery system – lubricious coating and drug delivery polymer; http://phx.corporate-ir.net/phoenix.zhtml?c=80353&p=irol-newsArticle&ID=880998&highlight=

NEVO sirolimus eluting stent delivery system – hydrophilic coating; Q1 2009 SRDX Conference Call

2. Medtronic

ENDEAVOR Stent Delivery System – hydrophilic coating; http://phx.corporate-ir.net/phoenix.zhtml?c=80353&p=irol-newsArticle&ID=791068&highlight=

3. CardioMind

SPARROW Drug Eluting Coronary Stent and delivery system –SynBiosys biodegradable polymer and hydrophilic coating; http://phx.corporate-ir.net/phoenix.zhtml?c=80353&p=irol-newsArticle&ID=1123791&highlight=

4. Nexeon MedSystems (formally Apollo Therapeutics, formally Paragon)

PROTEX stent – Finale Prohealing Coating; http://phx.corporate-ir.net/phoenix.zhtml?c=80353&p=irol-newsArticle&ID=1024489&highlight=

KODIAK stent modified for renal arteries – Finale Prohealing Coating; http://phx.corporate-ir.net/phoenix.zhtml?c=80353&p=irol-newsArticle&ID=1248906&highlight=

5. Reva Medical

Slide and Lock coronary stent? –SRDX technology not specified; http://www.designnews.com/article/CA6330957.html

6. Aeon Bioscience

Unknown Stent – SRDX technology not specified; http://www.brookwoodpharma.com/news/aeon.html

7. Devax, Inc

AXXESS Biolimus A-9 Eluting Bifurcation Stent Delivery System – Hydrophilic/hemocompatible coating; http://phx.corporate-ir.net/phoenix.zhtml?c=80353&p=irol-newsArticle&ID=843432&highlight=

8. Elixir Medical Corporation

Unknown Novolimus/Myolimus Drug eluting and bare metal stent delivery systems – Hydrophilic coating; http://phx.corporate-ir.net/phoenix.zhtml?c=80353&p=irol-newsArticle&ID=1220090&highlight=

9. Medlogics

COBRA? – Hydrophilic/hemocompatible coating; 2009 SRDX Annual Meeting, Listed on slide 23 as an additional DES customer

?. XTENT (1/25/09 going out of business?; #msg-35075314)

CUSTOM NX Delivery System – Hydrophilic coating; http://phx.corporate-ir.net/phoenix.zhtml?c=80353&p=irol-newsArticle&ID=856370&highlight=

?. X-Cell Medical (notably missing in 2/2/2009 Annual Meeting Webcast)

ETHOS 17 beta-estradiol eluting coronary stent – Bravo Drug Delivery Polymer Matrix; http://phx.corporate-ir.net/phoenix.zhtml?c=80353&p=irol-newsArticle&ID=903185&highlight=

---------
Related SRDX relationships include:

x. ThermopeutiX

Neurovascular stents – hydrophilic/hemocompatible coating technology; http://phx.corporate-ir.net/phoenix.zhtml?c=80353&p=irol-newsArticle&ID=713307&highlight=

x. AbbeyMoor Medical

Spanner Prostatic Stent – Polymer matrix technology; http://phx.corporate-ir.net/phoenix.zhtml?c=80353&p=irol-newsArticle&ID=877282&highlight=

x. Medtronics

AneuRx AAAdvantage Stent Graft on the Xcelerant Hydro Delivery System – hydrophilic coating; 1/23/2008 SRDX Q1 2008 Conference Call

Talent Abdominal Stent Graft delivery system - hydrophilic coating; 4/23/2008 SRDX Q2 2008 Conference Call