Replies to post #19868 on RespireRx Pharmaceuticals Inc (fka RSPI)

[bladerunner1717]

In support of what Neuro is talking about, SPPI had a CC today in which the not-very-much-trusted CEO said, in response to a question, that SSPI had narrowed its list down to three potential partners for its bladder cancer drug. That was enough to send the stock up 25% on much higher than average volume.

My thinking is that these much beaten down micro cap biotechs can move substantially on just the hint of a partnership, buyout, etc. As we get more clarity on these situations, the stock price responds even more. Look what has happened with GTCB.


Bladerunner

[gfp927z]

Neuro, Here's a repost of Varney's reply to Blatch from Monday, concerning the 'procedural problems' that occurred in RD-2 (see below). Varney mentions two problems that apparently messed up the 900 mg and 1500 mg data, but were corrected for the 2100 mg cohort -

1) Subjects were anxious, causing variability in the baseline measurements, so they brought them in for a 'dry run' in order to reduce their anxiety, and also excluded some subjects who were overly anxious.

2) Retightening the mask during each of the four measurements.

Of course the $64,000 question is whether these corrections were also made in RD-1, or was it too late to make changes there. I doubt the anxiety/'dry run' aspect was addressed in RD-1, though perhaps the more experienced University group running RD-1 didn't have the loose mask problem -


>>> "Thanks for your note Bob. I believe Roger was going to comment on this, but as you correctly stated, the clock ran out on him. It turns out the re-breathing procedure is a little more complicated than one might think, and a particularly sensitive measure. Some volunteers were anxious during the exercise, resulting in variable baseline data. This was reduced by bringing in the volunteers in the 2100mg group for a dry run first, so that during the first study their anxiety was reduced. It also gave us a chance to exclude those volunteers who were overly anxious with this exercise. There were also procedures put in place to refit the mask (i.e. re-tighten it) during each of the four measurements, and a couple of other details that appeared to improve the reliability of the measurements.
Regards, Mark" <<<