ELN/BIIB "He told me that many neurologists give tysabi as the last resort when all other options fail anyways. Its either 2/32000 chance of getting PML (which might not be fatal if caught early since those 2 patients are still alive) or being in a wheelchair for the rest of the life."
From my experience, if the drugs are failing, the prospects of being wheelchair bound are short and the prospects of death are ominous.