Replies to post #7416 on Entremed (ENMD)

[docaaron1]

Tborges, I respect your posts but I have to add that not trying is worse than failure.

A HIF-1a inhibitor should be used first as a pretreatment to chemo/radiation. As Dr. Dewhirst put it referring to chemo/radiation alone, "Unless the treatment is very effective in killing many if not most tumor cells, you are shooting yourself in the foot."

If you pretreated with Panzem or ENMD 1198 first then you do not allow the remaining tumor cells an HIF-1a escape mechanism. If you post-treat the tumor then HIF-1a levels may shoot up much higher than the selected dose of Panzem or ENMD 1198 can handle. As the Dewhirst article stated, “Because of the way solid tumors adapt the body's machinery to bring themselves more oxygen, chemotherapy and radiation may actually make these tumors stronger.”

I don’t know if they are using Panzem or ENMD 1198 on Senator Kennedy but I truly believe it would be the right thing to use first as a chemo/radiation pretreatment.

Aaron