Replies to post #11369 on GTC Biotherapeutics (fka GTCB)

[wjlknew]

jesse, I've wondered about this myself, although I don't know enough about it to do anything but wonder. From the Crucell website:

"Proteins

Recombinant Proteins – Recombinant proteins, such as blood factors, can be produced efficiently and safely on the PER.C6® cell line.

Antibodies – MAbstract® technology is used to identify strong binding and neutralizing antibodies for specific disease targets. Antibodies discovered in this way can then be produced on PER.C6® technology."

http://www.crucell.com/Research

[choguy]

Dear Jesse

Actually Per.C6 (and my namesake)are perfectly capable of expressing monoclonal antibodies. In fact the press release I included in my original post which trumpeted 15gm/L is with a monoclonal antibody. I am not aware of anyone trying this cell line with plasma proteins but given the success Per.C6 has handling the complexity of a monoclonal (multiple disulfide bonds, correct folding and assembly of two seperate chains)I see no reason a priori that it can't handle these too