Replies to post #7107 on GTC Biotherapeutics (fka GTCB)

[DewDiligence]

Auxiliary Reference List of Antithrombin Papers

[This list includes entries deemed to be of secondary importance for ATryn use in DIC/sepsis as well as entries relevant to other potential indications for ATryn. (A separate post accessible from the ReadMeFirst primer contains the primary scientific support for the use of ATryn in DIC/sepsis, including discussions of the Kybersept study.) Items within each heading are in reverse chronological order.]


Edits: Added Scripps sepsis paper posted by HobGlob
and two abstracts (one in CABG and one in FVIII deficiency).


DIC / Sepsis (see note above)
#msg-27215812 Scripps paper on sepsis MoA
#msg-26018349 Animal model of gram-positive septicemia
#msg-25907502 Pct of sepsis patients with DIC
#msg-25907331 Hemostatic changes
#msg-25511473 Ditto
#msg-25480768 Anti-inflammatory MoA
#msg-24523875 AT experience in ICU
#msg-24518865 SIRS
#msg-23829730 Animal model
#msg-14277430 Thrombomodulin in DIC
#msg-13512229 Meta-analysis
#msg-13150691 Animal model
#msg-13102302 Review re AT and APC
#msg-12975208 AT level has predictive value
#msg-12960346 Coagulation vs inflammation pathways
#msg-12743571 Animal model
#msg-12681781 ISTH score for DIC
#msg-11211288 Animal model of AT with tPA
#msg-10232620 Hemostatic changes
#msg-8452794 Reduction of D-dimer levels
#msg-7268415 ATryn itself effective in small study


Adverse outcomes during pregnancy
#msg-25630072 DVT
#msg-22037334
#msg-9327646
#msg-8988372
#msg-8256536
#msg-7834418
#msg-7050226


Hereditary deficiency
#msg-25630072 DVT rate (acute)
#msg-6794514 DVT rate (chronic)


Cancer
#msg-18991235 Pediatric ALL
#msg-12476761 Coagulation in cancer
#msg-12181584 Acute lymphoblastic leukemia
#msg-11804544 Use of anti-thrombotics in cancer
#msg-9460320 Liver mets in colon cancer
AT fragment in lung-cancer model


Chemistry and pharmacokinetics
#msg-13173404 Covalent linkage between AT and heparin
#msg-12100172 PK of AT from CHO cells
#msg-11801772 PK of ATryn vs plasma AT
#msg-7669971 AT glycosylation
#msg-6995560 AT glycosylation


Miscellaneous
#msg-27074306 FVIII deficiency
#msg-27074358 CABG
#msg-26018345 Burns
#msg-25952778 CABG
#msg-25590840 Increasing AT yield from CHO cells
#msg-25481215 Acute lung injury (preclinical)
#msg-25291011 Ditto
#msg-24268577 Stroke (preclinical)
#msg-20210837 ARDS
#msg-15039853 Burns
#msg-14277297 Polymicrobial peritonitis
#msg-14199820 Platelet adhesion
#msg-13345041 Thrombin increases cardiomyocyte death
#msg-13292817 Pediatric ECMO
#msg-12714409 Retinal vein occlusion
#msg-11611213 VOD combo treatment with defibrotide
#msg-11609770 SPK transplantation
#msg-10969504 Recurrent thromboembolism risk
#msg-10321740 Aneurysm surgery