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rustyboy

01/18/08 6:12 PM

#7083 RE: DewDiligence #7079

Also, I noticed from the Vienna study that ...."...low dose low molecular weight heparin was given...with similar dosing in both groups..."

While it states the heparin given was 'low dose', I believe the Leo trial precludes the use heparin because it interacts with antithrombin. I don't have any insight about how much heparin required to impair the antithrombin but even a small amount might well affect the result.

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randychub

01/18/08 6:59 PM

#7085 RE: DewDiligence #7079

"Thanks for your post. The takeaway message here is that antithrombin works best in DIC/sepsis patients with moderate disease; in severe sepsis, patients are generally too ill for any treatment to be effective."

I tried to discuss this awhile back regarding the market size with no takers. I own GTCB but I do think the market size given for sepsis has been fluffed.

R

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