Replies to post #6824 on GTC Biotherapeutics (fka GTCB)

[mouton29]

"But to get the inferiority delta you need to know what the rate with and w/o AT is historically (and then guess the SPA negotiated value)."

I may be wrong (I hope I am), but I thought we did not have an SPA. Dew we?

[DewDiligence]

Two points re the US Atryn trial:

1. The control arm is plasma-derived AT (using historical cases), not placebo (#msg-5609005).

2. There is no SPA.

Regards, Dew

[vinmantoo]

I already posted some data about DVT from a recent published paper. It occurs in about 40% in pregnant HD women and roughly 30% of HD patients following surgery. My assessment that one needs to see the historical controls about patients treated with plasma derived ATIII is correct. It can't be less than zero so we already know that rATIII is half way home from the European trial data uisnfg rATIII.