If you use a rate of 33% for DVT in HD patients, then one assumes in a 36 patient trials, 12 patient would have had a symptomatic DVT without any ATIII treatment. Now lets play with some statistics without any knowledge. If plasma derived ATIII was 75% effective, then 4 patients (12 x 0.75) would be expected to have developed symptomatic DVT. If it were 80% effective, then 2 patients ( 0.8 x 12). If it were it 90% effective, then 1 patient (12 x 0.9). That is why I said we need to know the historical data for plasma derived ATIII. If ATIII was only 75% effective, then we are just about home free.
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