Replies to post #4732 on GTC Biotherapeutics (fka GTCB)

[DewDiligence]

>If I read the previous studies re Atryn it looks like there is no effect on circulating protein C but there is with thrombomodulin. Can you help me understand how that difference might play out?<

Antithrombin inhibits a separate thrombin feedback loop from the thrombin feedback loop inhibited by thrombomodulin, which acts on protein C. Thus, it’s not a concern that antithrombin does not affect protein C—it’s not supposed to.

Let’s talk more about these technical matters after I’ve distributed the ART-123 paper. Regards, Dew