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DewDiligence

02/25/08 7:31 PM

#2431 RE: DewDiligence #1279

David Standring and Paul Fanning — EVP Biology and SVP
Human Resources, respectively — filed SEC Form-3 today.
Form-3 is the first filing for an insider who will subsequently
report all transactions in company shares on Form-4.

Neither Standring or Fanning is a new employee; they are new
Form-4 filers because they were promoted to executive-officer
status during 2007.

As of 2/22/08, Standring owned 60K shares and 135K options
while Fanning owned 1K shares and 130K options
. (Some of
these options are far out of the money).

http://www.sec.gov/Archives/edgar/data/1093649/000120919108012849/xslF345X02/doc3.xml
http://www.sec.gov/Archives/edgar/data/1093649/000120919108012851/xslF345X02/doc3.xml