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p3analyze

06/01/07 6:50 PM

#3994 RE: beachgal7711 #3993

I think the concern for pain may be overblown - but heck what do I konw- I totally missed the CR letter- so take my observation with a grain of salt.

If you care to follow the asco presentation- the first presentation under the abstract. The anti-DNDN camp may be relieved to find that pain was a significant predictor of survival as in the pivotal study in tax 237.

http://www.asco.org/portal/site/ASCO/menuitem.34d60f5624ba07fd506fe310ee37a01d/?vgnextoid=76f8201eb6...
However, perspicacious readers would notice that it took significant pain defined as on an analog scale of 10 or more, to be a predictor, as opposed to minimal pain (defined as an analog score of 3 or less), which is what 9902b has.

So I wouldn't be surprised what Gold said was true, espcially given bony mets is in the model and would correlate with pain to some extent.