Replies to post #3695 on GTC Biotherapeutics (fka GTCB)

[DewDiligence]

>…ADCC stands for Antibody-Dependent Cell-mediated Cytotoxicity. GTCB referred to it, somewhat casually, as Antibody-Dependent Cell Cytotoxicity, which could be a bit misleading. The antibodies themselves are not cytotoxic -- rather, they attract immune cells to target and destroy the cells that they bind to.<

Thanks for the clarification.

[jessellivermore]

Dr. Meade did an excellent job of explaining this at the recent annual meeting. The antibodies attach to the target cell. They do not destroy the cell but act as markers which attract "natural killer" cells. The "killers" attach to the glycolised end of the antibody and destroy the tageted cell. Alterations in glycolisation do not effect the affinity of the antibody for the target cells, they effect the affinity of the "killer cells" to the attached antibody marker.