"...Sigma-1 activation has been researched for more than 40 years. Despite all the promise, nothing clinically meaningful has been developed or commercialized by any company...."
Auvelity is a drug that its a sigma-1 receptor agonist that has been FDA approved for the treatment of MDD (Major Depressive Disorder) and recently approved for the treatment of agitation due to dementia and/or Alzheimer's disease.