Doc, you might want to look at my earlier post, but I'll repeat the idea. If NICE agrees to a quarter million for a full course of treatment with DCVax-L, what difference does it make if artisan production costs $25K and EDEN costs $10K.
If you remember correctly Advent was talking about adding shifts, to me that means it was possible to make the vaccine with just the day shift if they wished. It takes 8 days to make the vaccine, if it took full time of a single employee, how much could that possibly cost. Let's say it's 8 hrs. a day for 8 days, that's 64 man hours, what's a fair hourly wage, let's use $100 an hour which equates to over $200K a year, that's $6400 in labor time. Of course, if one employee can work 2, 3, 4 cleanrooms at a time the number goes down dramatically. I don't believe it's the cost of making it manually that makes it so different than the EDEN, it's the cost of building thousands of tiny cleanrooms and keep them operational. We have the 20 tiny cleanrooms, they'll add little more cost, but we don't want to build thousands more of them.
I don't believe that NWBO will have any problem at all providing DCVax-L right up to their capacity at a price that they and NICE agree with. I don't know how it will be structured, I'd hope they get something up front for making the vaccine, then so much for each dose with the sum if all doses are given exceeding something in the $300K range. If they average $200K or more per patient.
Gary