The trial results are scientifically invalid. It is obvious. How is it that anyone can question whether you can change the endpoints on a trial when you've already conducted an efficacy IA and know the recommendation was futility? When you do that (and they did it literally two weeks before data lock) you destroy the integrity of the trial. That's a fact. It is not disputable in the world of science. Next, they swapped out the trial's own control group (which showed placebo did better) in favor of external control groups that don't have patient-level data. It's an obvious effort to rig the results, which is frowned upon in the science community.
I have been saying this for months and months, and when it finally becomes public knowledge you're all going to act surprised and be like, "Gosh, if only we had known!" I guarantee it.