Replies to post #799090 on NorthWest Biotherapeutics Inc (NWBO)

[beartrap12]

Andrew, two years ago I asked the board about the cleanrooms/suites and got a well-researched answer from Hyperopia, which I saved in my notes. I hope, if he's watching this space, that he jumps in and speaks for himself, But short of that, I'll copy over his response to my question in 2023, and which I verified, at least in part, in the Catapult report and the 2023 10Q.

Hyperopia, 2023:

There are 2 manufacturing suites which are a total of about 4,000 square feet, but the number or type of cleanrooms, are unknown (to me), and this information wasn’t given in Catapult’s 2023 Manufacturing Report. However, what has been stated in various public documents, is the 1B buildout includes a sterility and QC testing lab, a large Grade C process development lab, and multiple Grade C cleanrooms where the Flaskworks systems will be deployed. Another interesting nugget, according to last month’s 10k, this Grade C process development space will also be used “for future work on next-generation technologies, including as part of collaborations that are under development.”

Me: At this point, the 1B buildout was complete and held C rooms. This is doubly confirmed by Catapult's 2023 Manufacturing Report that reports Advent owning 7 clean rooms, that include "2 Grade B rooms; 3 Grade C rooms; and 2 Grade D rooms". Catapult refers to them as cleanrooms, not suites. And we know that suites can hold several cleanrooms.

2023 10Q report:

The buildout of Phase 1B of the facility, which had begun in 2022, was completed. This included a large new Process Development (PD) lab that helped substantially with the Flaskworks development activities during the remainder of the year. The new PD lab will also be useful for future work on next-generation technologies, including as part of collaborations that are under development.

Me: Since we now know that Advent had 3 C rooms as far back as 2023 in the B1 suite that was just completed,when they were working on continued development of Flaskworks closed system, it makes perfect sense that they would conduct the work in the "large new Processing Development room," in that suite.

[meirluc]

Question to Slave1: With SOW-8 carried out at Swaston (recent 10-Q) and
requiring a functional Grade C cleanroom at that location, why did NWBO
feel it was important just about one month later to PR the construction of a new
Grade C manufacturing suite that will be completed maybe 3-6 months from now?
Could'nt such an announcement be incorporated into the next 10-Q? I am guessing
that there must have been a good reason for this early PR but I am also far from
certain that it means that no clean Grade C cleanrooms are presently functional
and we will have to wait for approval for another six months because only then, a
Grade C manufacturing suite will be functional.

By the way, Beartrap just wrote today (Post 799125) that already a number of years
ago, there were 3 Grade-C cleanrooms at Sawston. I don't know how much more
work those rooms required but 3 unfinished rooms years ago are better than none.