Brain atrophy has nothing to do with any endpoint being looked at for approval...so it is irrelevant. A2-73 could stop all heart attacks, lover disease, tooth decay, etc., and it wouldn't matter or be relevant as those would all need their own. Trials and 10+ years of BS data too.
What was mentioned was spot on and they come out closer to binary events because that is when there is the most traffic...also the article is centered around EMA approval, so why would it be released any other time?