Of course I am happy you responded, I have to go with the Peer Review since it is the ONLY source of reasonable response since I have to trust someone other than this message board....you at least pointed to experts!
Being unqualified myself, I have to trust experts who actually broke it down.
I can't make the math work. How do you explain it to the EMA? Do you say, "First you take 25% and then 37% and then 50% and that equals 100%!" I guess if no one at the EMA has gone to grade school then that might work.
You and Hoskuld are arguing about data in different time frames. 48 vs 192. You are both interpreting the data that Anavex released correctly. In table 5 and 6 in supplemental data WT had a significant 50% and mutant had a NS 25%. In the 192 week data the variant was even less and would be not significant. So by emphasizing the wild type that admit no long term significant effect on the variant