Can DCVax-L activate NK cells to eliminate cancer cells? Sure can. See those Tscm cells activated by DCVax-L? These cells are essential for immune memory.
Those CD14 monocytes will differentiate into macrophages once seeping into tumor tissue and the macrophages will suppress t-cells. But CSF1R inhibitor will prevent the differentiation. Can we expect a cure for cancer once CSF1R inhibitor is included?
BTW, it is a good idea to picture the scenario that Merck will decouple with Moderna sometime soon.
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