Replies to post #751253 on NorthWest Biotherapeutics Inc (NWBO)

[learningcurve2020]

It’s been such a long time I’ve forgotten some of it. That’s one of the many problems with forgoing quarterly calls and conferences. But that is coming back to me now, thanks. It actually might make some sense leaving some residual tumor tissue as it could be beneficial to the therapy, assuming L really shows any efficacy. If that’s right then it comes down to getting L into the patient as fast as possible. I’d think chemo should be dropped from the treatment, as well.

[Hopeforthefuture3]

Beartrap, on a relative basis for total resection vs partial resection dcvax performed well vs external control.
On absolute months of survival the total resection group had longer survival than those with partial resection. Surprisingly to me in the total resection group dcvax did not make a large difference vs external controls

[froggmister]

Dr. Liau on Partial Resection from Musella interview:

(slide 20, 23:35) This one was very surprising to us. There is actually a greater survival advantage in patients with significant residual disease (SRD) compared to minimal residual disease (MRD). As a surgeon we always taught and we thought that taking out as much of the tumor as possible leads to a better prognosis, and that still is the case; you see in the MRD group that survival is still longer than the survival in the SRD cohort, but the relative survival advantage is greater in this group. What this kind of suggests is that perhaps…one thing that dendritic cell vaccination that we know it does is that it gets T-cells into the tumors, and perhaps in order to have a more diverse repertoire of antigen presentation in epitope spreading, there may need to be some residual tumor still there so T-cells that are still there, once they get into the tumor and get activated there may need to be residual tumor there to enhance the immune response and promote epitope spreading. This hypothesis perhaps needs further validation but I found that to be very interesting in this case.

[norisknorewards]

This is what helps (in his mind) lc create a case to suggest he is too uneducated to possibly have been manipulating retail because he is green on the topic.

Go down swinging, amiright