“What I expect to happen is a jump in share price followed by rampant short selling”.
— I agree with the above statement but not the reasons you gave for short selling. Short selling will happen because they know LP has nothing meaningful up her sleeve post approval except fluff PRs like Oncovir partnership, combo trial (but no cash to run and accelerate it), and so on, so it would be easy money for them again.
I do agree that the only news that will get shorts to move away from their games and give up will be a validation from big pharma including cash injection. Outside that, nothing else will matter and they will continue to question every move and short at every opportunity. It doesn’t help that this management team has a really bad history and have lost investors ton of money and opportunity cost over the last 10-15 years.