Dstock, Thanks for the article, makes me learn about heart disease, a new topic for me. Makes sense to me that DCs can be educated to target a specific antigen.
Atherosclerosis (build up of plaque in the arteries) is the heart disease issue. Too much LDL means LDL gets trapped on the artery walls. That triggers an immune response to clean it up. Immune cells (macrophages, etc) eat the LDL, but in the process, they can get overwhelmed and then turn into fat cells that get stuck on the artery wall creating plaque. That is why some say atherosclerosis is an inflammatory disease.
A thought. If DCs can be educated to recognize specific antigens, then another option is to educate them to modulate the immune response (as opposed to inflammatory). A lot of options, not just fight but to be "diplomats", as DCs are the "General" in the immune process.
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