Ex, I agree with what you said. The follow-up paper was to have been a couple years (or more) after the initial paper. Yes I know the study is now very old
One tumor injected and when immune response caused sufficient enlargement from this then treatment was stopped due to pseudoprogression being labeled progression. Also, some tumors simply became totally necrotic and were later surgically removed. A pancreatic cancer patient saw this happen and perhaps the sarcoma patient that had a huge tumor simply collapse if I recall correctly and one lung cancer patient went back to swimming after treatment. When tumors are stopped from growing they die from the inside out. Distal tumors also were affected in some cases by Direct indicating some systemic effect. Those distant tumors were not treated directly which is the necessary part of treatment with Direct in order to pick up all antigen targets in each heterogenous tumor to prevent escape. You know this; ). Best wishes.
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