Replies to post #724395 on NorthWest Biotherapeutics Inc (NWBO)

[Horseb4CarT]

I’m not qualified to state method of application with any authority, however one guess is that a lysate might be produced from processed virus cells if that is possible.

If one could assemble enough viral material, possibly even a blend if viral materials to cover multiple strains, and process it (maybe like tumor processing ir maybe different) and pulse the immature DCs, then that would be similar to the cancer approach.

The company that dstock posted a link to seems to already include virus(HIV) in their plans so they may be a good place to look for information on their approach?

[Hopeforthefuture3]

Gary, listen to some of the presentations by Bosch on direct. It injected into the tumor where it is to pick up the antigens and then the dendritic cells transfer the target to the t-cells. Phase 2 was to inject multiple tumors and more than 1.time. held promis but as of yet never happened

[SkyLimit2022]

Gary,

A member of the Nobel committee mentioned the possibility of DC technology playing a role in the treatment of other diseases such as MS and diabetes (pasted below), so the question you raised is an excellent one. There was also a recent Lancet paper about a French/Swiss study involving DC technology for HIV. I would also mention that I believe the novel DC technology at Roswell (that NWBO now owns) does not have to be loaded with antigens from the tumor and might have the potential for broader application. I believe I read that it is easier to make too.

Some love Halloween time 🎃 and the beginning of the fall season. As a science enthusiast, I love October because it’s Nobel season!

It’s a great time to remember that NWBO is a company that was built on a rock-solid foundation of Nobel Prize-winning science, and brilliant physicians like Dr. Linda Liau and Dr. Pawel Kalinski could also one day be candidates for the Nobel Prize for their ground-breaking discoveries of novel combination therapies to overcome tumor resistance!








Dr. Steinman was awarded the Nobel Prize for discovering the dendritic cell. In 2018, James P. Allison and Tasuku Honjo were awarded the Nobel Prize in Physiology or Medicine for their pioneering work in cancer therapy through the discovery of immune checkpoint inhibitors.

Today, Dr. Linda Liau and Dr. Pawel Kalinski are combining dendritic cell technology with checkpoint blockade technology to reach new levels of efficacy and healing for patients! UCLA and Roswell are studying how these two Nobel Prize-winning discoveries can be combined to treat multiple distinct cancers!





Recently, we commemorated the loss of the great Dr. Ralph Steinman 13 years ago on September 30th.

“We know he will live on through his scientific contributions.”

Dr. Steinman’s legacy is changing the field of cancer immunotherapy today, and his invaluable Nobel Prize-winning work lives on at UCLA, King’s College and Roswell Park, among other cutting-edge institutions.

The recent evolution of dendritic cell technology has been vast, and Dr. Steinman’s prophetic words foreshadowed the future and DCVax-L. In the last 3 minutes of the YouTube video, Dr. Steinman describes the “first generation of this approach” which used only ONE single antigen. Consider that DCVax-L can present HUNDREDS of distinct antigens today!

The Nobel Prize in Physiology or Medicine has proven significant historically, and a great number of the discoveries that were awarded the prize have proven quite impactful.

The award represents the credible collective opinion of the 50 distinguished members of the Nobel Assembly and the opinions of any number of distinguished international medical experts whom the members may choose to consult. By their own published criteria, their decision to award the prize means that they believe the medical breakthrough will impact humanity globally.

To put the relatively recent awards for dendritic cell discovery and PD-1 in perspective, consider that checkpoint inhibitors have only existed commercially for 10 years. Drugs such as Keytruda have been blockbusters, and the full impact of PD-1 as a drug class is yet to be realized as the technology continues to evolve to include additional new products, such as subcutaneous versions.

Other examples of Nobel Prize-winning medical breakthroughs include:

X-Ray Technology, 1901
Penicillin, 1945
Insulin, 1923
MRI Imaging Technology, 2003
Monoclonal Antibodies, 1984
CRISPR Technology, 2020

These discoveries and many others that won the Nobel Prize have gone on to either revolutionize medical practice or create entire industries around their commercialization.



https://www.nobelprize.org/prizes/medicine/

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