Replies to post #720085 on NorthWest Biotherapeutics Inc (NWBO)

[dstock07734]

SkyLimit2022,

I like your post. Moderators should sticky it.

Lisa Butterfield did a clinical trial on dendritic cell vaccine on melanoma. An expert certainly understands well what other experts have achieved.

Multiple Antigen-Engineered DC Vaccine for Melanoma
https://clinicaltrials.gov/study/NCT01622933

Immuno-metabolic dendritic cell vaccine signatures associate with overall survival in vaccinated melanoma patients
https://www.nature.com/articles/s41467-023-42881-4

Dendritic cell vaccines targeting tumor blood vessel antigens in combination with dasatinib induce therapeutic immune responses in patients with checkpoint-refractory advanced melanoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593702/

[ilovetech]

SkyLimit - Great post! Agree with dstock. Your post should be stickied!

[exwannabe]

Yes, that is a nice interview.

A few notes from it. Around 23:30 she is disusing the actual antigen used and is talking about purified specific antigens and getting away from lysates.

"So here, you take the blood cells and they pretty normal on the surface anyway, and you can culture them in GMCSFas a growth factor, and IL-4 for differentiation. and load them with purified forms of antigen, and this is getting away from the tumor lysate where you would loading them with tumor antigens that you know about and don;t know about, which is good, and IL-10 and tgf beta and all these negative regulators."

I.E., the multiple antigens is good, but comes at a cost of negative regulators in the lysate.

Not trying to say one approach is clearly better than another. Just that many experts in the field are not able to see what the scientists on this message board assert is obvious.

Oh, she also seams to support RNA based approaches.

[learningcurve2020]

I see my article on GVAX didn't go unnoticed. You're welcome.

[CrashOverride]

It's obvious that Big Pharma are bringing their checkbook!