Replies to post #720003 on NorthWest Biotherapeutics Inc (NWBO)

[eagle8]

Here’s a brief summary.
1. DCVax activates T cells to fight the cancer tumor. It is very effective but the effect is mitigated somewhat by a tumor defense. The tumor sends out PD-L1 proteins to attach to the T cell’s PD-1 receptor. When activated, this is a checkpoint that down-regulates the T cell.

2. So, a PD-1 inhibitor, aka checkpoint inhibitor (CI), neo-adjuvant drug was added. It is very effective in fighting this tumor’s defense.

(Thanks to Chiugray).