Replies to post #678640 on NorthWest Biotherapeutics Inc (NWBO)

[hyperopia]

ski, I think there are still many unanswered questions about DCVax. I know that all of us are hopeful that the budgetary constraints that have burdened this company will be over soon, and they will finally begin more clinical trials to get some of those answers.

This reminded me that I sent a note about this study on brain tumors and circadian rhythms to Dr. Liau a few years ago, (I didn’t have access) and she replied that she was interested.

Alterations to the circadian clock make brain tumours vulnerable
nature NEWS AND VIEWS | 14 October 2019

The body’s circadian clock ensures the rhythmic expression of some genes across the day. The catalogue of genes under circadian control changes in an aggressive brain cancer — a discovery that might open up a new avenue for treatment.
* By Guiomar Solanas & Salvador A. Benitah

All organisms have an internal circadian clock, which ensures that physiological functions occur at the right time of day — for instance, that the intestine, pancreas and liver are ready to metabolize food when you eat rather than when you are sleeping. Writing in Cancer Discovery, Dong et al.1 report that the cells responsible for initiating a specific type of aggressive brain tumour, glioblastoma, rely on an altered circadian clock to grow. What’s more, drug-based inhibition of the cells’ molecular clock can kill them.
Access options
https://www.nature.com/articles/d41586-019-03042-0

There have been others since - this one’s open access:

Dendritic cells direct circadian anti-tumour immune responses
nature Article Open access Published: 05 December 2022

https://www.nature.com/articles/s41586-022-05605-0