I’m a bit late to this game but I’m quite confused as to how a person with a brain abscess that was found to contain a tiny bit of calcified GBM (now re-classified as an Astrocytoma wild type) who started on this forum only a few days ago, and who’s first postings suggested he had no postulations as to the outcome of a filed MAA has worked his way into a position that he actually now IS making a claim that said MAA will be rejected at the coming CHM meeting based upon testimony he gave to the MHRA and NHS. How am I doing so far?
First, am I correct in asserting you’re upset that you’re still alive 9 years after a diagnosis of GBM because you feel you were misdiagnosed? Is it your contention that if you really had a non methylated GBM by today’s WHO classification you’d never have made it this far without any treatments beyond the surgery and some chemo?
Second, just so we’re clear; while rare, brain abscesses are indeed found in GBM and Astrocytoma, among other types such as Meningiomas (Meningiomas are outside the blood/brain barrier so not so unusual). And when found they’re usually extensions from sinus infections, which can be extensions of erosion of a deep tooth abscess into the maxillary sinus, then further extension from there. So I’m not sure if you’re claiming that you never had cancer in the first place because you had a simple abscess or if you’re claiming you’ve had a fantastic recovery from an Astrocytoma without ever having much treatment beyond the original surgery and chemo/rad?
Third; I’m confused as to what damage you’re claiming that would have sent you to do a series of interviews with regulators regarding the DCVax clinical trial? What part, if any, played a role in your current perspective? Are you claiming the Nurse administrator of the trial coerced you to join the trial that you claim you didn’t join? Or is it that you claim that King’s College was so eager to get you into the trial because of what you call a “favorable presentations and overall genomic profile”? What I see from 2015 you didn’t have a favorable genomic profile in the non methylated status of your tumor at least. Are you claiming you were part of a “cherry picking” of trial participants? Further, I’m a little confused that you were diagnosed in 2015 (must have been before May because the partial hold would prevent any screening of new patients after that) with a GBM4 and were the “first person in the world” be be reclassified under the new WHO classification in 2021, but it was 9 years later; which would be now, correct? It took 3 more years to be the first in the world to have a reclassification from the original pathology? Interesting for sure
Fourth; You were on Lamotrigine for seizures. Were you on a steroid regimen at that time? There’s some developing evidence some anti seizure medications, especially with steroids (but also without) may inhibit brain tumor growth
What I’m seeing makes no sense; you’ve got some axe to grind but it’s not clear what precisely it is. Any clarification on the above points would be appreciated
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