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Investor2014

11/02/23 2:57 PM

#437898 RE: georgejjl #437896

I see it is time once again for a Set Theory lesson. I hope with care and attention you can see as follows is true.

There is an All Patients Superset of 21 physical patients grouped into 6 Analysis Subsets each based on certain analysis constraints?

The All Patients n of 21 <> 43, which is the sum of the Subsets n = 2 + 6 + 11 + 16 + 3 + 5?

The total number of actual physical patients in the analysis Subsets Group1 and Group2 is 6, not 8?

The two patients in Group1, that are also members of Group2, are the reason that the Group2 graph is not going below baseline until after week 70?

That there really are only 2 'super responder' patients in the P2a AD trial that just seems to get better and stabilise as time passes, whereas all other patients decline after week 70, or actually before if Group2 where not to include the Group1 patients?

Those 2 'super responders' are not a good basis for extrapolating how many 'super responders' there will be in the PDD OLE or the P2b/3 AD trial?

None of this has anything to do with "Probability and Random Processes".

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Investor2014

11/02/23 3:00 PM

#437900 RE: georgejjl #437896

Complete home grown conjecture nonsense!!!

The APOE e4 allele causes the concentration of Anavex 2-73 in the blood plasma to be a high concentration due to pharmacokinetics and pharmacodynamics.


There i nothing in any publication to support your theory.

Correlation is not necessarily causation and in fact seldom is.