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georgejjl

10/28/23 2:30 PM

#437451 RE: Steady_T #437450

Dr. Randi Hagerman

This medication can be a boon. I think in general for aging and certainly for aging syndromes like Parkinson’s Disease and Alzheimer’s and I can’t wait to start it on other neuro-developmental disorders like Fragile X Syndrome.

I am very excited about this medication and also as I age I would definitely like to take Anavex myself.

I’m excited that this is a break through medication and for not just Rett Syndrome but other disorders of aging and also neuro-degeneration.



Good luck and GOD bless,
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Jonjones325

10/28/23 2:43 PM

#437452 RE: Steady_T #437450

Thanks.

I’m having a hard time understanding why our Alz data doesn’t virtually guarantee us getting AA.

We met the definition of a successful trial with the one primary and our secondary. We have the gold standard biomarker that the Mabs were approved with.

We have the reduction in brain atrophy and safety to boot. On what grounds could the FDA deny us?

Small trial? I thought these results were harder to get with a small trial thus our signal is stronger.

All said before but the decision seems straightforward. Even without the ADL data since elements of ADL are seen within the CDR. Not sure what there is not to like.

All I see is winning!
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attilathehunt

10/28/23 4:39 PM

#437458 RE: Steady_T #437450

And how long ago was it when Dr. Randi Hagerman said that?


I also remember her saying on a presentation call that she thought it was already approved.


She believes in it 100% so why didn't Chris pushed for compassionate use then?

So many questions regarding his decision making. Coupled that with his prognosis of milestones makes him aa very ineffective leader and thus why the piece is where it is at. Only positive RETT results with the release of full TLD will end the price suppression. Anything less the move up will be short lived.

Com'on Chris - Get it right for once!!!!