Yes, and I believe Lykiri noted that almost all or all German patients were in that low absolute lymphocyte count allowable group coming in starting in 2014 and they likely evented much more quickly in the SOC/placebo group around the same time that a likely look in 2015 at treatment induced pseudoprogression was being done because of PFS discernment issues. The annual report from Fraunhofer that same year 2015, indicated that enrollment occurred to the point statistically necessary. Best wishes.