Replies to post #423553 on Anavex Life Sciences Corp (AVXL)

[WolfofMia]

Always positive about anything Anavex.

[Investor2014]

It is of course commonly known that calculating an ADCS-ADL mean is hugely complex in comparison to a simple RSBQ mean.

If it turns out the RSBQ mean is too time consuming to get right, Anavex may just throw in a few Odds Ratios with a bit of glamorous sounding marketing words added.

That should make message boards very happy and kept speculating for another few years on the promise of more peer reviewed papers and patent applications.

As bonus question, does anybody know how many ex-FDA statisticians it takes to calculate an ADCS-ADL mean?

[12x]

Were the 5-18y patients titrated to 30mg in Excellence trial? It was 5mg in US Rett adult p2 trial, then 30mg in Adult p2b/3 trial even though 20% Rett patients didn’t reach 30mg. From the AE slide, 15% of 509-patient AD p2b/3 trial patients can’t tolerate more than 10mg. However the 132-patient PDD p2 trial didn’t report any tolerability issues with neither 30 nor 50mg groups.

Is Anavex trying to confirm the optimal treatment dose is 30mg for Rett and 50mg for AD/PD with the expectation that a portion of the patients can’t tolerate that target doses, therefore titration is always required until a precision medicine is found?

[georgejjl]

What effect on price paid for monoclonal ant-body treatment for Alzheimer's will there be for Medicare coverage gap (also called the "donut hole")???

Most Medicare drug plans have a coverage gap (also called the "donut hole"). This means there's a temporary limit on what the drug plan will cover for drugs.

Not everyone will enter the coverage gap. The coverage gap begins after you and your drug plan have spent a certain amount for covered drugs. Once you and your plan have spent $4,660 on covered drugs in 2023, you're in the coverage gap. This amount may change each year. Also, people with Medicare who get Extra Help paying Part D costs won’t enter the coverage gap.

https://www.medicare.gov/drug-coverage-part-d/costs-for-medicare-drug-coverage/costs-in-the-coverage-gap

Good luck and GOD bless,

[georgejjl]

Doc328:

What effect on price paid for monoclonal ant-body treatment for Alzheimer's will there be for Medicare coverage gap (also called the "donut hole")???

Most Medicare drug plans have a coverage gap (also called the "donut hole"). This means there's a temporary limit on what the drug plan will cover for drugs.

Not everyone will enter the coverage gap. The coverage gap begins after you and your drug plan have spent a certain amount for covered drugs. Once you and your plan have spent $4,660 on covered drugs in 2023, you're in the coverage gap. This amount may change each year. Also, people with Medicare who get Extra Help paying Part D costs won’t enter the coverage gap.

https://www.medicare.gov/drug-coverage-part-d/costs-for-medicare-drug-coverage/costs-in-the-coverage-gap

Good luck and GOD bless,