dstock07734,
The mouse model you cited is testing L or an L like product and that needs help in large established tumors.
The Direct mouse model did not get the spacing for Direct figured out exactly but knew that checkpoint response needed to be controlled so they used a checkpoint inhibitor which then helped to establish immune memory.
The real threat NWBO poses is the one that come by establishing the fact that no additional treatments are needed. Whether that comes by more trials (very, very likely) to establish this or not, I am nearly 100% certain that in most cases nothing else will be needed. I know some folks that would benefit from having this option right now and some no longer with us that should have had the opportunity. The science is way ahead of “the process”. Best wishes.
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