Congratulations on doing your own homework... and finding that older discussion that was based on the AVATAR trial and the related FDA information and thinking at that time.
The context of that discussion was regarding agreed upon endpoints and data analysis with small sample sizes and thus AUC was used in that analysis.
But guess what you should have learned today that "The Rett Syndrome Behavior Questionnaire (RBSQ) total score and Clinical Global Impression Improvement Scale (CGI-I) score are co-primary endpoints in the statistical analysis plan with specified linear mixed-effects models for repeated measures (MMRM) as the primary analysis methods."
To be an effective bearish FUD'ster explain more fully the issues with MMRM. Not dredging up an out of context comment on AUC.
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