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DFRAI

12/11/22 4:50 PM

#391590 RE: georgesk #391589

Pretty much shows disease slightly better than baseline and much superior to Lecanemab results which are declining from baseline
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avxl_going_long

12/11/22 5:26 PM

#391593 RE: georgesk #391589

"improvement" is the operative word here
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frrol

12/11/22 5:52 PM

#391600 RE: georgesk #391589

It is, practically speaking. But over a 48 week period, which is a sufficiently long time, someone with AD is going to have a definite decline (eg, average 4.11 points for our placebo arm, with just .86 SE). Stability, or even slight improvement, is clearly clinically significant.