Xena,
If we're right about the DCVax's working in many solid cancers a multi-billion share count will still bring a three digit or greater share price as annual sales go into the hundreds of billions, or more. If we're wrong and only GBM works, sales will still go into the billions and you'll be seeing double digit share prices.
In short, I wouldn't be overly concerned about the O/S as long as the earnings potential appears to be as great as it appears to be.
Gary
Bullish