I have had Twitter PM conversations with AF in the past. He is convinced NWBO analyzed the data post hoc after learning OS would be a better endpoint and PFS failed. He thinks NWBO draw the bull's eye after it threw the darts.
As I told ex I told AF that the FDA permits biotech to change endpoints and to amend their SAP prior to data lock of their medical trial. He believes NWBO changed endpoints just after TLD was presented on May 10, with the changing of clinicaltrials.gov after May 10 as evidence. I told him that clinicaltrials.gov can be changed by the biotech whenever they wish, the website is independent of (amended) SAP submission with the FDA. I send him a screenshot of the EMA website where the changed endpoints showed up at the beginning of Oct 2020 making his dart-throwing argument mute. But he wont have any of it and is lying on purpose.
I will never communicate with these awful horrible excuse of a men again.
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