If history does not repeat itself with respect to NWBO and journal publications there will be no cause for disappointment.
But if the article does not appear in NEJM or a truly equivalent journal but a lesser journal then that is truly a disappointment.
Even if we get in somewhere like NEJM If it turns out that NWBO has not used the last 2 years well to unleash an unstoppable cascade of good news happen with a REAL PR and IR effort then that will be a disappointment albeit not as severe.
When they rug pull people on October 5, 2020 and it’s now October 2022 and everyone is still Waiting for Godot then yes the standard they need to meet has gone up considerably from what it was even in October 2021.