Replies to post #520827 on NorthWest Biotherapeutics Inc (NWBO)

[Margin Buu]

It's the truth.

Flipper, post 519498:

In the Optune trial, in the treatment arm, only 16 of 466 (3.4%) were alive, beating hearts, at five years (from time zero). In the Stupp protocol arm, according to recent reports, 0 out of 229 were alive, beating hearts, at five years, but according to Stupp back then, 2 out of 229 were alive at five years, beating hearts. (Time = two years from last randomized patient’s entry into the trial)

At just two years after the last patient was randomized into the Optune arm. only 57 (including 16 above) (12%) out of 466 patients were still alive somewhere at two or more years from randomization. The likelihood is five year survival, beating hearts, was under 5% (from time zero) at five years had they followed the trial further to five years from last randomization.. Which they did not. At the same time as they stopped the trial two years after last patient was enrolled, only 16 of 229 (7%) patients were still alive. The likelihood is less than 2% (Stupp protocol) might live until five years (from time zero) had the trial been followed until five years from last patient’s randomization into trial. Imo.

Optune shamelessly exaggerates their five year survival, and they demonstrate how research without follow up can make a mockery of the KM curve.

All estimates reflect survival from time zero.

The Optune trial was never ever blinded for survival.

[X Master]

Ok, Optune has been around for over 5 years, SHOW ME THE DATA!