Replies to post #516628 on NorthWest Biotherapeutics Inc (NWBO)

[HyGro]

The only people calling it "breakthrough' are NWBO fanboys. No independent expert in the field would would call a highly manipulated clinical trial "breakthrough."

As NWBO has repeatedly stated, the naive OS data is confounded, the rGBM treatment arm was a post hoc data dredged outcome, not part of the original NAIVE GBM trial design. Then there was the mysterious FDA trial stop that the company has refused to identified the cause. No independent clinician would call all these issues and manipulations a credible trial. Only ones touting it have conflicts of interest and are receiving money directly or indirectly from NWBO. Sorry, not credible.

Your Viagra example also included a comprehensive clinical trial process including well-controlled, large-scale trials, not manipulated trials with confounded data, tossed out primary endpoint when it failed, etc. etc.

[no2koolaid]

To your point...

Clinical trials are about discovery.

And rediscovery, as you likely know...

Thalidomide was introduced in 1957 and promoted for anxiety, trouble sleeping, "tension", and morning sickness. While it was initially thought to be safe in pregnancy to stem morning sickness, horrific birth defects led to the medication being removed from the market in 1961. Today, Thalidomide is used as a first-line treatment in multiple myeloma in combination with dexamethasone or with melphalan and prednisone to treat acute episodes of erythema nodosum leprosum and for maintenance therapy.

[dr_lowenstein]

Yes—the DCVax P3 was a breakthrough tria

LOL a trial that was only successful after data manipulation